Dominions II: The Ascension Wars is a turn-based fantasy strategy title and the direct sequel to the sleeper hit, Dominions: Priests, Prophets, and Pretenders. Designed and developed by Illwinter Game Design of Sweden, Dominions II is a game of godhood that is as massive in scope as the heavens themselves. Rich in detail and options, the highly addictive gameplay will suck you into the realm of 3 A.M. gaming and not let you go. Play solo or against sixteen human opponents and create your own Gotterdammerung!
Here's Shrapnel's official Press release.

License: commercial (~$40)

Additional System Requirements: OpenGL / 3D acceleration